Chemokine and Inflammation.
نویسندگان
چکیده
منابع مشابه
Questions about chemokine and chemokine receptor antagonism in renal inflammation.
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease. Industry has launched huge programs for the development of chemokine antagonists, and clinical trials with chemokine and chemokine receptor antagonists are ongoing. However, chemokine biology remains an area of unexpected discoveries. Here we...
متن کاملTargeting the chemokine network in renal inflammation.
Chemokines and their receptors are involved in the pathogenesis of renal diseases. They mediate leukocyte recruitment and activation during initiation as well as progression of renal inflammation. Infiltrating leukocyte subpopulations contribute to renal damage by releasing inflammatory and profibrotic cytokines. All intrinsic renal cells are capable of chemokine secretion on stimulation in vit...
متن کاملAtypical chemokine receptors in renal inflammation.
Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic angiogenesis. In addition to the classical G protein-couple...
متن کاملChemokine receptors in inflammation: an overview.
Chemokine receptors play a key role in directing the migration of inflammatory cells into various injured or infected organs. However, migration of inflammatory cells into tissues can in itself be a cause and amplifier of tissue damage and disease, particularly in chronic autoimmune or allergic disorders. On this basis, much effort is currently devoted at the identification of molecular signals...
متن کاملAtypical Chemokine Receptors in Renal Inflammation
Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic angiogenesis. In addition to the classical G proteincoupled...
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ژورنال
عنوان ژورنال: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
سال: 1999
ISSN: 0300-9173
DOI: 10.3143/geriatrics.36.82